Structure-function Analysis of NADE: Identification of regions that mediate NGF-induced Apoptosis
نویسندگان
چکیده
Division of Molecular Oncology, Department of Otolaryngology / Head & Neck Surgery and Pathology, College of Physicians & Surgeons, Columbia University, New York NY 10032, USA *Molecular Oncology Laboratory, RIKEN (Institute of Physical and Chemical Research), Ibaraki 305-0074, Japan ¶To whom correspondence and requests for materials should be addressed: Division of Molecular Oncology, Department of Otolaryngology/Head & Neck Surgery and Pathology, College of Physicians & Surgeons, Columbia University, 630 West 168th St., P&S 11-451, New York, NY 10032. Tel.: 1-212-305-1701; Fax: 1-212-305-1736; Email: [email protected] §Present address: Department of Otolaryngology, School of Medicine, Kitasato University, Kanagawa 228-8555, Japan
منابع مشابه
Structure-function analysis of NADE: identification of regions that mediate nerve growth factor-induced apoptosis.
Nerve growth factor (NGF) can induce apoptosis in neural cells via activation of the low affinity neurotrophin receptor p75NTR. NADE (p75NTR-associated cell death executor) is a p75NTR-associated protein that mediates apoptosis in response to NGF by interacting with the death domain of p75NTR in 293T, PC12, and nnr5 cells (Mukai, J., Hachiya, T., Shoji-Hoshino, S., Kimura, M. T., Nadano, D., Su...
متن کاملNADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR.
The low affinity neurotrophin receptor p75NTR can mediate cell survival as well as cell death of neural cells by NGF and other neurotrophins. To elucidate p75NTR-mediated signal transduction, we screened p75NTR-associated proteins by a yeast two-hybrid system. We identified one positive clone and named NADE (p75NTR-associated cell death executor). Mouse NADE has marked homology to the human HGR...
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Recently, a 22 kDa protein termed p75(NTR)-associated death executor (NADE) was discovered to be a necessary factor for p75(NTR)-mediated apoptosis in certain cells. However, the possible role for p75(NTR)/NADE in pathological neuronal death has yet been undetermined. In the present study, we have examined this possibility in vivo and in vitro. Exposure of cortical cultures to zinc induced both...
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